产品货号：
Z37763
中文名称：
Hu CD3 zeta/CD247 (pY153) Purified抗体
英文名称：
Anti-Hu CD3 zeta/CD247 (pY153) Purified Antibody (Clone#EM-17)
产品规格：
0.1mg(C100)
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Hu CD3 zeta/CD247 (pY153) Purified Antibody (Clone#EM-17) |
| 指标别名 | CD247;CD247 molecule;CD3 ZETA;CD3H;CD3Q;CD3Z;T cell receptor T3 zeta chain;T3Z;TCRZ |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse |
| 应用范围 | FCM,WB |
| 基因名称 | CD247 |
| 克隆号 | EM-17 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | A phospho specific peptide corresponding to the amino acids surrounding tyrosine 153 of mouse CD3 zeta linked to KLH.The mouse monoclonal antibody EM-17 recognizes phosphorylated intracellular tyrosine 153 of CD3 zeta chain (CD247),which is a component of TCR/CD3 complex expressed on T cells. |
| 计算分子量 | 19kDa |
| 成分 | Phosphate buffered saline (PBS),pH7.4,15mM sodium azide |
| 纯化方式 | Purified by protein-A affinity chromatography. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Store at 2～8℃.Do not freeze. |
| 背景资料 | CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex.T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma,CD3 delta,CD3 epsilon and CD3 zeta (CD247).These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11.The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules.This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits.CD3 may play a role in TCR-induced growth arrest,cell survival and proliferation. |
| Uniprot ID | P20963 |
| 基因名全称 | CD247 molecule |
| 蛋白名全称 | T-cell surface glycoprotein CD3 zeta chain |
| 推荐稀释比 | Western blotting:2 ～ 5μg/mL;positive control:Jurkat cells lysate treated with pervanadate,splenocyte lysate of Balb/c or F1 mouse treated with pervanadate,non-reducing conditions recommended. Flow cytometry:Intracellular staining;recommended dilution:1～4μg/mL;positive control:Jurkat cells treated with pervanadate. |
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